PORTLAND, OR — While the term “palliative care” is usually associated with ameliorating pain and discomfort at the end of life, it appeared to have other benefits for veterans, according to a new study. In this cohort study of 23 ,154 patients with advanced lung...
Agent Orange Linked to Overall Head/Neck Cancers
PORTLAND, OR — Agent Orange exposure might have had more effect than previously assumed on development of head and neck cancers, according to a recent study. A report in the Oral Oncology journal described how self-reported Agent Orange exposure was linked with...
What Is the Relationship Between Parkinson’s Psychosis, Treatment?
LONDON, UK – For years, common treatments -- levodopa and dopamine agonists (dopamine replacement therapy [DRT]) – have been implicated in Parkinson's disease psychosis. A report published in Movement Disorder Clinical Practice pointed out that the relationship...
Study Finding Could Detect Alzheimer’s Disease Earlier
SAN DIEGO — People who were diagnosed as having “objectively-defined subtle cognitive difficulties” appeared to accumulate amyloid more quickly than those deemed cognitively normal, according to a new study. That information could potentially improve early detection...
Two Subtypes of Gulf War Illness Identified
WASHINGTON — Gulf War illness appears to be more complex than previously thought, according to a study using brain imaging of veterans with the condition. The report in Brain Communications discussed how varying abnormalities were detected after moderate exercise that...
New Study Examines Role of Military Deployment in Global Disease Transmission
CHAPEL HILL, NC — The explosive emergence in December 2019 of a novel coronavirus in Wuhan, China, prompted governments around the globe to restrict travel from the affected region in an attempt to limit international spread of the disease. While these efforts focused...
Aggressive Chemo-Immunotherapy Found Safe for Older Patients With CLL Treatments
MINNEAPOLIS — Even though chronic lymphocytic leukemia is a disease of older adults, with median age of 68 years at diagnosis, clinical trials on chemo-immunotherapy agents rarely included patients of advanced age, according to a new study. Noting the strong...
New Antibiotics Are an Increasingly Important Front in Fight Against Anthrax
WASHINGTON — When Project BioShield was first signed into law 15 years ago, the nation had few medical countermeasures to respond to bioterrorism. Since then, the Biomedical Advanced Research and Development Agency has supported 27 projects using Project BioShield...
Recent Veterans Are Different in Some Ways Than Those Who Came Before
High Rates of Deployment, Combat Affected Them Mentally, Physically WASHINGTON—This likely will come as little surprise to the VA and DoD medical personnel who care for them, but recent veterans really are very different from those who came before them. A recent...
Study Looks at Trichomonas Vaginalis Infection, Cancer Link
LOUIS—The protist Trichomonas vaginalis causes a common, sexually transmitted infection, some research has raised the possibility that it might contribute to the development of chronic prostate conditions, including benign prostatic hyperplasia and prostate cancer. A...
Prostate Cancer Survival Unimproved with Androgen Blockade Addition
SAN DIEGO—While the addition of androgen deprivation therapy to radiation therapy improves survival in patients with intermediate- and high-risk prostate cancer, it remained unknown whether combined androgen blockade with a gonadotropin-releasing hormone agonist and a...
Post-Surgical Prostate Cancer Surveillance Not Guideline-Concordant
ANN ARBOR, MI—Does guideline concordance with annual postoperative prostate-specific antigen surveillance increase when PSA values exceed 4 ng/mL, even though that represents a screening threshold that is not relevant after surgery? That was the question raised in an...
Researcher Uses VA EMR to Track Social Factors Linked to Veteran Suicide
PITTSBURGH—It’s long been understood that social stress factors such as violence, homelessness, unemployment, relationship problems and other factors can all contribute to veterans’ suicidal ideation and suicide attempts. For the first time, that link can be...
Concerns About GI Events Continue With Sodium Polystyrene Sulfonate
OTTAWA, ONTARIO — Continuing concerns are being raised about the gastrointestinal safety of sodium polystyrene sulfonate, which is commonly prescribed for the treatment of hyperkalemia.
Researcher’s Focus on Walking Helps Improve Health, Safety of Veterans
GAINESVILLE, FL — When people want to describe themselves as uncoordinated, they might say they have trouble walking and chewing gum at the same time. However, the act of walking—one of the most basic human skills—is not nearly as simple as that phrase makes it sound.
Genetic Mutations Affecting Response to Drugs Are Common in Veterans
SALT LAKE CITY — A massive VA study revealed that 99% of veterans have at least one genetic mutation known to affect response to specific drugs, including some commonly prescribed antidepressants, anticoagulants, antivirals, oncology medications and statins. That raises the question of who should be tested for which variants and when, which has stirred lively debate within the VA.
Combat PTSD/TBI Increases Amygdala Size in Military Patients
SAN DIEGO — The region of the brain that processes fear, anxiety, aggression and similar emotions is larger in veterans and active-duty service members with combat-related post-traumatic stress disorder and mild traumatic brain injury than those with brain injuries only.
Processes Similar in Schizophrenia, Psychotic Biopolar Disorder
NASHVILLE, TN — Processes leading to impairment in schizophrenia and psychotic bipolar disorder might be more similar than previously assumed, according to a new study.
Following Guidelines Reduced Mortality in Veterans at High Risk of Recurrent Stroke
INDIANAPOLIS — Meticulously following clinical guidelines in VA patients who suffered transient ischemic attack or nonsevere ischemic stroke reduced by nearly one-third their risk of death within a year, according to a new study.
Trying to Determine What Leads to Tobacco Cessation in Vets
MINNEAPOLIS — Incidental pulmonary nodules are commonly found on routine chest imaging, but not enough is known about smoking behaviors among patients with IPNs or characteristics of patient-clinician communication that may contribute to these behaviors.
Political Issues Related to VA’s Limited Approval of Esketamine for Depression
WASHINGTON — A VA panel this summer opted not to add the new depression medication esketamine, Spravato, to the department’s formulary in the usual way. This came despite strong support from President Donald Trump and an effort by VA officials to fast-track the drug for approved use at VA facilities.
Tests Show No Lung Changes for Recent Veterans
SAN ANTONIO — Significant airborne hazards were reported during military conflicts in southwest Asia, including geologic dusts, burn pit emissions, chemical exposures, and increased rates of smoking.
New Guidelines Recommend TNFi Biologics as Initial Psoriatic Arthritis Treatment
BIRMINGHAM, AL — For the first time, new guidelines have recommended the use of tumor necrosis factor inhibitor biologics as initial therapy for psoriatic arthritis.
VA Study Shows Benefit of PCSK9 Inhibitors After Maximizing Other Therapies
HOUSTON—Veterans who have experienced acute coronary syndrome within the past year face a substantial risk of a repeat event. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors significantly reduce that risk, but determining who would benefit most and when they should be initiated has been challenging.
VA-led Study Finds U.S. MS Prevalence Is Double Previous Estimates
WASHINGTON—Researchers and policy makers estimated that 300,000 to 400,000 people in the U.S. had multiple sclerosis in 2010, but new data indicates that number grossly undercounted the number of people affected by the neurological disease.
Metformin Reduces Dementia Risk in Black Veterans With T2D
ST. LOUIS—Use of metformin for Type 2 diabetes significantly reduces the risk of dementia among African American male veterans older than 50, according to a large observational cohort study.
New Biomarker for MS Discovered; Could Replace MRI for Detection
BALTIMORE—A University of Maryland research team has discovered a biomarker that can determine whether a patients has multiple sclerosis or is relapsing, thanks to VA funding.
Decompensated Diabetes More Common in Certain Racial, Age Groups
ATLANTA—Which diabetes patients are most likely to have decompensated diabetes, defined as diabetic ketoacidosis and hyperosmolar hyperglycemic state?
Tight Glycemic Control Increases Fracture Risk in Veterans with Diabetes
DURHAM, NC — Diabetes mellitus among older men has been associated with increased bone mineral density but paradoxically increased fracture risk, according to a study in the Journal of Bone and Mineral Research.1
Debate Continues on Esketamine Efficacy and Safety for Depression Treatment
PHILADELPHIA—Is esketamine a revolutionary treatment for depression or just another moderately effective adjunctive medication with some potentially serious risks? The VA’s Medical Advisory Panel leaned toward the latter position when it decided in June to approve the use of esketamine on a nonformulary basis for individuals who have previously failed at least two trials of other antidepressants.
