For 70 years, physicians and researchers have been aware of secondary primary malignancies (SPM) in patients with multiple myeloma.
The Role of Cardiac Screening for CLL Patients on Ibrutinib
Ibrutinib transformed treatment for chronic lymphocytic leukemia (CLL) when introduced in 2014. While it continues to be widely used, the Bruton’s tyrosine kinase (BTK) inhibitor is associated with a significant risk of cardiac adverse events, particularly cardiac arrhythmias.
Improving a Risk Model for VTE in Lung Cancer Patients Receiving ICI
The St. Louis VA investigators and colleagues at the Fred Hutchison Cancer Institute in Seattle sought to identify specific risk factors that predispose patients to ICI-associated VTE and could be used to stratify outpatients with non-small cell lung cancer (NSCLC) for thromboprophylaxis.
Increased Risk of COVID-19 Breakthrough Persists in MM Patients After Boosting
BOSTON—Since early in the COVID-19 pandemic, physicians have been aware of the greater risk posed by the SARS-CoV-2 virus to patients with compromised immune systems. Among patients with multiple myeloma (MM), more than 30% died of the virus in early waves before the...
Novel Agents Supplant Chemotherapy as 1L CLL Therapy in VA
For years, chemotherapy provided the only hope for patients with chronic lymphocytic leukemia (CLL).
VA Researchers Illuminate a New Blood Cancer, a Novel Type of CLL
In the case of chronic lymphocytic leukemia (CLL) with prolymphocytic progression, a newly defined and very rare type of cancer, the scale of the VA and the number of patients it treats with leukemia allowed VA researchers to describe the characteristics and progression of the disease and begin to understand how it responds to current therapies.
VA Works to Comply With Expansion of Eligibility Under New PACT Act
Now that the first major provisions of the PACT Act went into effect at the beginning of last month, what happens next?
Pharmacist Email Alerts Don’t Reduce Opioid, Benzodiazepines Prescribing
Email alerts sent from pharmacists to practitioners who prescribe opioids and benzodiazepines fail to reduce concurrent prescribing of these medications, which can put patients at risk of overdose, according to a new study.
Demographics of Hypertrophic Cardiomyopathy Patients Appear to Be Changing
The typical hypertrophic cardiomyopathy patient appears to have changed somewhat, according to a new study, which pointed out that “clinicians are encountering a phenotype of hypertrophic cardiomyopathy evolving from the disease recognized several years ago.”
Biomarkers Can Stratify outcomes in Some ICI-Treated NSCLC Patients
In non-small cell lung cancer (NSCLC), there are limited predictive biomarkers for anticancer immunotherapy. Proposed as candidate biomarkers for immune checkpoint inhibitors (ICI) in patients with advanced NSCLC are tumor-infiltrating lymphocytes (TILs).
VA Risk Prediction Model Guides Choice of Treatment for Stage I NSCLC
The problem with options is choosing. Until recently, oncologists did not need to choose between treatment alternatives for stage I lung cancer. If a patient could withstand surgery, the decision was made.
VA Researchers Lead Effort to Rethink Surgery for Non-Small Cell Lung Cancer
Amidst all the changes in therapies and protocols for treating stage I non-small cell lung cancer (NSCLC), the first step in treatment has remained the same for decades: surgery.
What Affects Compliance with Thyroid Nodule Surveillance?
Is thyroid nodule surveillance compliance affected by patient demographics or plan type? That was the question addressed in the recent retrospective case series from 2010 to 2018.
Higher Subclinical Papillary Thyroid Cancer Rates Not Found in Middle Age
How does age affect underlying subclinical papillary thyroid cancer (PTC)? A meta-analysis of autopsy studies investigated how subclinical PTC prevalence changes over the lifetime.
Should All Thyroid Incidentalomas Be Evaluated?
It is not unusual for a clinician to identify thyroid incidentalomas on non-thyroid dedicated imaging studies. However, discovered, clinical guidelines recommend evaluation of all thyroid incidentalomas to risk-stratify for cancer.
Polypharmacy Complicates Management of CLL, Other Cancers
WINSTON-SALEM, NC.—Managing multiple medications poses a challenge for many older patients. Forty percent of people in the United States over the age of 65 regularly take five or more drugs, meeting the definition of polypharmacy. For patients with hematologic...
VHA Data: Migraine Is a Commonly Treated Condition Among Veterans
Migraine is a commonly treated condition at the Veteran’s Health Administration (VHA), with more than half-million veterans being diagnosed during a 12-year study period, according to a recent study.
COVID-19 Can Lead to Long-term Neurologic Disorders; Even Veterans With Mild Illness Could Be Affected
Patients face an increased risk of long-term neurologic conditions after suffering from COVID-19, including stroke, cognition and memory disorders, nervous system disorders, mental health disorders and more, according to a study examining the long-term effects of COVID-19.
Military Study: Biomarkers Can Identify Risk for TBI-Related Dementia
Several studies have found a link between traumatic brain injury (TBI) and an increased likelihood of late-life dementia. The mechanisms driving the relationship have remained elusive, however.
Model Helps Predict Mortality Prognosis for AD, Dementia Patients
Dementia is a leading cause of morbidity and mortality worldwide and is associated with increased mortality risk.
Glitazones Decrease Risk of Alzheimer’s, Other Dementia in Veterans’ Study
The risk of dementia, including Alzheimer’s disease, appeared to be reduced in veterans prescribed an older class of type 2 diabetes drugs, glitazones.
Adjuvant Chemotherapy for All Stage II or III NSCLC? VA Study Urges Caution
Patients with non-metastatic non-small cell lung cancer (NSCLC) face a substantial risk of recurrence and death from the disease even after potentially curative surgical resection.
VA Demonstrates Ethnic Variations in Response to NSCLC Treatment Not Dependent on Access
The Food and Drug Administration approval of the first immune checkpoint inhibitor for non-small lung cancer (NSCLC) changed the course of the disease for many patients and increased survival rates.
Dietician Mary Julius Champions VA’s Virtual Diabetes Education Program
When Mary Julius was diagnosed with Type 1 diabetes in 1974, the world was a very different place. There were only approximately 4.5 million Americans who had been diagnosed with diabetes.
DoD and VA Update Guideline for Management of Major Depressive Disorder
Expansion of interventional psychiatry and updated algorithms to help guide physicians in making choices about therapies for depression are among important updates included in the newly revised 2022 VA-DoD Clinical Practice Guideline for Management of Major Depressive Disorder.
Association Found Between Battlefield TBI, Subsequent Cardiovascular Disease
Traumatic brain injury (TBI) was common among U.S. servicemembers deployed to Iraq and Afghanistan, with up to 20% sustaining at least one TBI. Although the survival rate for such injury was high, research has suggested TBI is associated with a wide variety of adverse effects, including dementia, epilepsy and mental health conditions.
Smokers With Preserved Lung Function Not Helped by Dual Bronchodilators
Long-term smokers often have serious respiratory symptoms, but without airflow obstruction. A new study questioned whether those patients should be treated with drugs used for chronic obstructive pulmonary disease (COPD).
Pandemic Didn’t Delay Colonoscopies for Veterans With ‘Red Flag’ Symptoms
Concerns have been raised over the past few years that, because of the COVID-19 pandemic, VHA patients with “red flag signs or symptoms” of colorectal cancer (CRC) did not receive prompt colonoscopy workups.
Hepatitis C Drugs Show Promise in Reducing PTSD Symptoms in Veterans
Direct-acting antivirals used in the treatment of the hepatitis C virus might improve symptoms of post-traumatic stress disorder (PTSD), potentially offering a new therapeutic option for a prevalent disease with few approved medications, according to a new study.
VA Program Successfully Reduces Post-Operative Opioid Prescriptions
Drug overdose is the leading cause of injury-related death in the United States. For many, initial exposure to opioids occurs in the hospital following surgery, and current studies show that up to 75% of post-operative patients have unused opioid pills after discharge.
